Kisspeptin Modulation of Reproductive Function

Kisspeptin is a peptide expressed mainly in the infundibular nucleus of hypothalamus. plays crucial role regulation reproductive functions. It regarded as most important factor responsible for control hypothalamic–pituitary–gonadal axis, onset puberty, and menstruation fertility. activity influences numerous processes such steroidogenesis, follicular maturation, ovulation, ovarian senescence. The identification kisspeptin receptor mutations that cause hypogonadotropic hypogonadism has initiated studies on puberty. Pathologies affecting neurons secreting play major development PCOS, functional hypothalamic amenorrhea, perimenopausal vasomotor symptoms. analogs (both agonists antagonists), therefore, may be beneficial therapy those afflicted with pathologies. aim this review to summarize influence physiology pathology system humans, well its potential use therapy.